Chemical formula: C₂₀H₂₉N₅O₃ Molecular mass: 387.484 g/mol PubChem compound: 5639
Urapidil interacts in the following cases:
The antihypertensive action of urapidil can be exacerbated by concomitant administration of alpha-receptor blockers including those given for urological conditions, vasodilators and other blood pressure lowering drugs, and in conditions involving hypovolaemia (diarrhoea, vomiting) and alcohol.
In patients with kidney and/or liver function disorders it may be necessary to reduce the dose of urapidil.
As no adequate experience yet exists of combining treatment with ACE inhibitors, this is not at the moment recommended.
The combination of urapidil with baclofen should be considered cautiously, as baclofen can increase the antihypertensive effect.
Cimetidine administered concomitantly inhibits the metabolism of urapidil. Urapidil serum concentration is likely to increase by 15%, so that dosage reduction should be considered.
Consideration should be given to the following concomitant administration:
Precautions for use of urapidil in cardiac insufficiency caused by mechanical function impairment, such as stenosis of the aortic or mitral valves, pulmonary embolism or limited cardiac action due to pericardial disease.
Urapidil during pregnancy is not recommended. There is no adequate data from the use of urapidil in pregnant women. Studies in animals have shown reproductive toxicity without teratogenicity. Because of the limitations of the studies, the potential risk for humans is unknown.
In the absence of data on excretion into mother’s milk, breast-feeding is not recommended in case of treatment with urapidil.
Urapidil has minor influence on the ability to drive and use machines. The response to treatment may vary from one patient to another. This applies most particularly at the start of treatment, after changes to treatment, or in the event of concomitant alcohol intake.
In the assessment of undesirable effects, the following frequency ranges are used: Very common (≥1/10), common (≥1/100 to <1/10), uncommon (≥1/1,000 to <1/100), rare (≥1/10,000 to <1/1,000), very rare (<1/10,000), not known (cannot be estimated from the available data).
Very rare: Thrombocytopenia*
Uncommon: Palpitations; tachycardia; bradycardia; feeling of pressure or pain in the chest (similar to angina pectoris)
Common: Nausea
Uncommon: Vomiting; diarrhoea; dry mouth
Uncommon: Fatigue
Very rare: Oedema
Very rare: Reversible increase in liver-specific enzymes
Common: Dizziness; headache, vertigo
Uncommon: Sleep disturbances
Very rare: Restlessness
Very rare: Increased urge to urinate or exacerbation of urinary incontinence
Rare: Priapism
Rare: Nasal congestion
Uncommon: Sweating
Rare: Symptoms of cutaneous allergic reactions (pruritus, rashes, exanthema)
Uncommon: Orthostatic dysregulation
* In very rare cases, a reduction in thrombocyte count has been observed simultaneously with administration of urapidil. No causal relationship with the urapidil treatment has been established – for example by immune haematological tests.
In the majority of cases the following undesirable effects can be attributed to too rapid a fall in blood pressure; however, experience shows that they disappear within minutes, even during slow infusion, so that interrupting the treatment must be decided depending on the degree of severity of the undesirable effect.
Very Common (≥1/10), Common (≥1/100 to <1/10), Uncommon (≥1/1,000 to <1/100), Rare (≥1/10,000 to <1/1,1000, Very rare (<1/10,000), Not known (cannot be estimated from the available data).
Very rare: Thrombocytopenia
Uncommon: Palpitations; Tachycardia; Bradycardia; Chest pressure sensation; Respiratory distress; Cardiac dysrhythmias
Common: Nausea
Uncommon: Vomiting
Uncommon: Fatigue
Very rare: Asthenia
Common: Dizziness, Headaches
Very rare: Restlessness
Rare: Priapism
Rare: Nasal congestion
Uncommon: Sweating
Rare: Symptoms of cutaneous allergic reactions (pruritus, rashes, exanthema)
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