The World Health Organization's ATC classification organizes medical drugs based on therapeutic properties, chemical composition, and anatomy. It helps make essential medicines readily available globally and is widely used in the pharmaceutical industry.
Level | Code | Title | |
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1 | C | Cardiovascular system | |
2 | C01 | Cardiac therapy | |
3 | C01D | Vasodilators used in cardiac diseases |
Code | Title | |
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C01DA | Organic nitrates | |
C01DB | Quinolone vasodilators | |
C01DX | Other vasodilators used in cardiac diseases |
Active Ingredient | Description | |
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Dilazep |
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Glyceryl trinitrate |
Glyceryl trinitrate is a vasodilator and is used for angina of effort. Vasodilation is achieved by the releasing of free redical nitric oxide which activates guanylate cyclase and increases synthesis of guanosine 3′ and 5′-monophosphate with resultant effects on the phosphorylation of proteins in smooth muscle. If taken in excess, its vasodilatory effect can cause headache. |
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Heptaminol |
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Isosorbide dinitrate |
Isosorbide dinitrate is an organic nitrate, which in common with other cardioactive nitrates, is a vasodilator. |
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Isosorbide mononitrate |
Isosorbide mononitrate is an organic nitrate, which, in common with other cardioactive nitrates, is a vasodilator. It produces decreased left and right ventricular end-diastolic pressures to a greater extent than the decrease in systemic arterial pressure, thereby reducing afterload and especially the preload of the heart. |
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Molsidomine |
Molsidomine is a long acting vasodilating drug. Molsidomine, a sydnonimine acting as a heterocyclic direct nitric oxide donor, has been used for the treatment of patients with stable angina pectoris. It’s also established drug for the treatment of coronary heart disease. Molsidomine is metabolized in the liver to the active metabolite linsidomine. Linsidomine is an unstable compound that releases nitric oxide (NO) upon decay as the actual vasodilating compound. |
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Nicorandil |
Nicorandil is a derivative of the niacinamide that is structurally combined with an organic nitrate. It provides a dual mode of action leading to relaxation of vascular smooth muscle. Nicorandil is a potassium-channel opener that causes vasodilatation of arterioles and large coronary arteries. Its nitrate-like properties produce venous vasodilation through stimulation of guanylate cyclase. Nicorandil has a direct effect on coronary arteries without leading to a steal phenomenon. The overall action improves blood flow to post-stenotic regions and the oxygen balance in the myocardium. |
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Pentaerithrityl tetranitrate |
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Propatylnitrate |
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Trapidil |
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Vericiguat |
Vericiguat is a stimulator of soluble guanylate cyclase (sGC). Heart failure is associated with impaired synthesis of nitric oxide (NO) and decreased activity of its receptor, sGC. The pharmacodynamic effects of vericiguat are consistent with the mode of action of a sGC stimulator resulting in smooth muscle relaxation and vasodilation. |
Title | Information Source | Document Type | |
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CARMIL XL Prolonged release tablet | Medicines & Healthcare Products Regulatory Agency (GB) | MPI, EU: SmPC | |
CEDOCARD Solution for infusion | Υπουργείο Υγείας (CY) | MPI, EU: SmPC | |
DEPONIT Transdermal patch | Medicines & Healthcare Products Regulatory Agency (GB) | MPI, EU: SmPC | |
DERMATRANS Transdermal patch | Health Products Regulatory Authority (IE) | MPI, EU: SmPC | |
ELANTAN LA Prolonged release capsule | Medicines & Healthcare Products Regulatory Agency (GB) | MPI, EU: SmPC | |
GLYTRIN Sublingual spray, solution | Medicines & Healthcare Products Regulatory Agency (GB) | MPI, EU: SmPC | |
IKOREL Tablet | Medicines & Healthcare Products Regulatory Agency (GB) | MPI, EU: SmPC | |
ISMO Retard prolonged-release tablet | Medicines and Medical Devices Safety Authority (NZ) | MPI, EU: SmPC | |
ISOKET 1 mg/ml Concentrate for solution for injection / infusion | Medicines & Healthcare Products Regulatory Agency (GB) | MPI, EU: SmPC | |
ISOKET RETARD Prolonged release tablet | Medicines & Healthcare Products Regulatory Agency (GB) | MPI, EU: SmPC | |
ISOKET Solution for infusion or injection | Medicines & Healthcare Products Regulatory Agency (GB) | MPI, EU: SmPC | |
ISOMONIT Prolonged release tablet | Health Products Regulatory Authority (IE) | MPI, EU: SmPC | |
ISORDIL TITRADOSE Tablet | FDA, National Drug Code (US) | MPI, US: SPL/Old | |
ISOSORBIDE MONONITRATE / CARMIL / MONOMIL Tablet | Medicines & Healthcare Products Regulatory Agency (GB) | MPI, EU: SmPC | |
MONOREM Prolonged-release tablet | Υπουργείο Υγείας (CY) | MPI, EU: SmPC | |
MONOREM Tablet | Υπουργείο Υγείας (CY) | MPI, EU: SmPC | |
NITRO-DUR Transdermal patch | FDA, National Drug Code (US) | MPI, US: SPL/Old | |
NITROCINE Solution for infusion | Health Products Regulatory Authority (IE) | MPI, EU: SmPC | |
NITRODERM TTS Transdermal patch | Υπουργείο Υγείας (CY) | MPI, EU: SmPC | |
NITROLINGUAL Sublingual spray | Medicines & Healthcare Products Regulatory Agency (GB) | MPI, EU: SmPC | |
NITRONAL Solution for infusion | Medicines & Healthcare Products Regulatory Agency (GB) | MPI, EU: SmPC | |
NYZAMAC Prolonged-release capsule, hard | Medicines & Healthcare Products Regulatory Agency (GB) | MPI, EU: SmPC | |
RECTOGESIC Rectal ointment | Medicines & Healthcare Products Regulatory Agency (GB) | MPI, EU: SmPC | |
TRANSIDERM NITRO Transdermal patch | Medicines & Healthcare Products Regulatory Agency (GB) | MPI, EU: SmPC | |
VERQUVO Film-coated tablet | European Medicines Agency (EU) | MPI, EU: SmPC |