ATC Group: C09AA02 Enalapril

The World Health Organization's ATC classification organizes medical drugs based on therapeutic properties, chemical composition, and anatomy. It helps make essential medicines readily available globally and is widely used in the pharmaceutical industry.

Position of C09AA02 in the ATC hierarchy

Level	Code	Title
`1`	C	Cardiovascular system
`2`	C09	Agents acting on the renin-angiotensin system
`3`	C09A	ACE inhibitors, plain
`4`	C09AA	ACE inhibitors, plain
`5`	C09AA02	Enalapril

Defined daily dose

The DDD is the assumed average maintenance dose per day for a drug used for its main indication in adults. The DDD is a unit of measurement and does not necessarily reflect the recommended or Prescribed Daily Dose. Therapeutic doses for individual patients and patient groups will often differ from the DDD as they will be based on individual characteristics (such as age, weight, ethnic differences, type and severity of disease) and pharmacokinetic considerations.

Code	Route	Amount	Notes
ORAL	Oral	10 mg
PAREN	Parenteral	10 mg

Active ingredients in C09AA02

Active Ingredient
Enalapril
Enalapril is hydrolysed via hepatic CES 1 to the active metabolite enalaprilat, which acts as an ACE inhibitor. ACE is a peptidyl dipeptidase which catalyses the conversion of angiotensin I to the vasoconstrictor substance angiotensin II and hence inhibition of ACE results in decreased plasma angiotensin II. This also leads to increased plasma renin activity and decreased aldosterone secretion. The mechanism of action of enalapril is therefore primarily via the suppression of the RAAS. However, ACE is identical to kininase II, and so enalapril may also exert its effects by blocking the degradation of bradykinin, a potent vasodepressor peptide.

Related product monographs

Document	Type	Information Source
ALAPREN Tablet	MPI, Generic	Health Products Regulatory Authority (ZA)
AQUMELDI Orodispersible tablet	MPI, EU: SmPC	European Medicines Agency (EU)
ENAP Tablet	MPI, EU: SmPC	Health Products Regulatory Authority (IE)
INNOVACE Tablet	MPI, EU: SmPC	Medicines & Healthcare Products Regulatory Agency (GB)
KORANDIL Tablet	MPI, EU: SmPC	Υπουργείο Υγείας (CY)
RENITEC Tablet	MPI, Generic	Pharmaceutical Benefits Scheme (AU)
VASOTEC Tablet	MPI, US: SPL/Old	FDA, National Drug Code (US)