The World Health Organization's ATC classification organizes medical drugs based on therapeutic properties, chemical composition, and anatomy. It helps make essential medicines readily available globally and is widely used in the pharmaceutical industry.
| Level | Code | Title | |
|---|---|---|---|
| 1 | J | Antiinfectives for systemic use | |
| 2 | J01 | Antibacterials for systemic use | |
| 3 | J01D | Other beta-lactam antibacterials | |
| 4 | J01DE | Fourth-generation cephalosporins |
| Code | Title | |
|---|---|---|
| J01DE01 | Cefepime | |
| J01DE02 | Cefpirome | |
| J01DE03 | ||
| J01DE51 |
| Active Ingredient | Description | |
|---|---|---|
| Cefepime |
Cefepime is a broad-spectrum, bactericidal antibiotic, with activity against a wide range of Gram-positive and Gram-negative bacteria, including many strains resistant to aminoglycosides or third generation cephalosporins. It has a reduced affinity for beta-lactamases. |
|
| Cefepime and Enmetazobactam |
Cefepime exerts bactericidal activity by inhibiting peptidoglycan cell wall synthesis as a result of binding to and inhibition of penicillin-binding proteins (PBPs). Enmetazobactam is a penicillanic acid sulfone beta-lactamase inhibitor structurally related to penicillin. Enmetazobactam binds to β-lactamases and prevents the hydrolysis of cefepime. It is active against class A ESBLs. |
|
| Cefozopran |
|
|
| Cefpirome |
|
| Title | Information Source | Document Type | |
|---|---|---|---|
| EXBLIFEP Powder for concentrate for solution for infusion | European Medicines Agency (EU) | MPI, EU: SmPC | |
| EXBLIFEP Solution for injection | FDA, National Drug Code (US) | MPI, US: SPL/PLR | |
| RENAPIME Powder for solution for injection / infusion | Medicines & Healthcare Products Regulatory Agency (GB) | MPI, EU: SmPC | |
| ROXIPIME Sterile powder for injection | Health Sciences Authority (SG) | MPI, Generic |
