ATC Group: J04AK Other drugs for treatment of tuberculosis

The World Health Organization's ATC classification organizes medical drugs based on therapeutic properties, chemical composition, and anatomy. It helps make essential medicines readily available globally and is widely used in the pharmaceutical industry.

Position of J04AK in the ATC hierarchy

Level Code Title
1 J Antiinfectives for systemic use
2 J04 Antimycobacterials
3 J04A Drugs for treatment of tuberculosis
4 J04AK Other drugs for treatment of tuberculosis

Group J04AK contents

Code Title
J04AK01 Pyrazinamide
J04AK02 Ethambutol
J04AK03 Terizidone
J04AK04 Morinamide
J04AK05
J04AK06
J04AK07
J04AK08

Active ingredients in J04AK

Active Ingredient

Bedaquiline is a diarylquinoline. Bedaquiline specifically inhibits mycobacterial ATP (adenosine 5'-triphosphate) synthase, an essential enzyme for the generation of energy in Mycobacterium tuberculosis. The inhibition of ATP synthase leads to bactericidal effects for both replicating and non-replicating tubercle bacilli.

The pharmacological mode of action of delamanid involves inhibition of the synthesis of the mycobacterial cell wall components, methoxy-mycolic and keto-mycolic acid. The identified metabolites of delamanid do not show anti-mycobacterial activity.

Ethambutol is bacteriostatic. It is effective against Mycobacterium tuberculosi and M.bovis with an MIC of 0.5–8µg per ml. The exact mechanism of action is unknown. While it has activity against some atypical mycobacteria including M.Kansasii, activity against other micro-organisms has not yet been reported.

The mechanism of action of pretomanid is thought to involve inhibition of the synthesis of cell wall lipids under aerobic conditions and generation of reactive nitrogen species under anaerobic conditions. Reductive activation of pretomanid by a mycobacterial deazaflavin (F420)-dependent nitro-reductase is required for activity under both aerobic and anaerobic conditions.

Pyrazinamide exhibits tuberculostatic activity. Pyrazinamide is active only at an acid pH, and it is therefore active mainly on the tubercle bacilli located within the cell.

Related product monographs

Document Type Information Source  
 DELTYBA Dispersible tablet MPI, EU: SmPC European Medicines Agency (EU)
 DELTYBA Film-coated tablet MPI, EU: SmPC European Medicines Agency (EU)
 DOVPRELA Tablet MPI, EU: SmPC European Medicines Agency (EU)
 ETIBI Tablet MPI, CA: SPM Health Products and Food Branch (CA)
 MYAMBUTOL Film-coated tablet MPI, US: SPL/Old FDA, National Drug Code (US)
 SIRTURO Tablet MPI, EU: SmPC European Medicines Agency (EU)
 ZINAMIDE Tablet MPI, EU: SmPC Medicines & Healthcare Products Regulatory Agency (GB)