The World Health Organization's ATC classification organizes medical drugs based on therapeutic properties, chemical composition, and anatomy. It helps make essential medicines readily available globally and is widely used in the pharmaceutical industry.
| Level | Code | Title | |
|---|---|---|---|
| 1 | L | Antineoplastic and immunomodulating agents | |
| 2 | L01 | Antineoplastic agents | |
| 3 | L01F | Monoclonal antibodies and antibody drug conjugates | |
| 4 | L01FG | VEGF/VEGFR (Vascular Endothelial Growth Factor) inhibitors | |
| 5 | L01FG01 | Bevacizumab |
| Active Ingredient | Description | |
|---|---|---|
| Bevacizumab |
Bevacizumab binds to vascular endothelial growth factor (VEGF), the key driver of vasculogenesis and angiogenesis, and thereby inhibits the binding of VEGF to its receptors, Flt-1 (VEGFR-1) and KDR (VEGFR-2), on the surface of endothelial cells. Neutralising the biological activity of VEGF regresses the vascularisation of tumours, normalises remaining tumour vasculature, and inhibits the formation of new tumour vasculature, thereby inhibiting tumour growth. |
| Title | Information Source | Document Type | |
|---|---|---|---|
| ALYMSYS Concentrate for solution for infusion | European Medicines Agency (EU) | MPI, EU: SmPC | |
| AVASTIN Concentrate for solution for infusion | European Medicines Agency (EU) | MPI, EU: SmPC | |
| AYBINTIO Concentrate for solution for infusion | European Medicines Agency (EU) | MPI, EU: SmPC | |
| OYAVAS Concentrate for solution for infusion | European Medicines Agency (EU) | MPI, EU: SmPC |
Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide.
