The World Health Organization's ATC classification organizes medical drugs based on therapeutic properties, chemical composition, and anatomy. It helps make essential medicines readily available globally and is widely used in the pharmaceutical industry.
| Level | Code | Title | |
|---|---|---|---|
1
|
L | Antineoplastic and immunomodulating agents | |
2
|
L04 | Immunosuppressants | |
3
|
L04A | Immunosuppressants | |
4
|
L04AX | Other immunosuppressants | |
5
|
L04AX01 | Azathioprine |
The DDD is the assumed average maintenance dose per day for a drug used for its main indication in adults. The DDD is a unit of measurement and does not necessarily reflect the recommended or Prescribed Daily Dose. Therapeutic doses for individual patients and patient groups will often differ from the DDD as they will be based on individual characteristics (such as age, weight, ethnic differences, type and severity of disease) and pharmacokinetic considerations.
| Code | Route | Amount | Notes |
|---|---|---|---|
| ORAL | Oral | 0.15 g | |
| PAREN | Parenteral | 0.15 g |
| Active Ingredient |
|---|
|
Azathioprine is a pro-drug of 6-mercaptopurine (6-MP). 6-MP is inactive but acts as a purine antagonist and requires cellular uptake and intracellular anabolism to thioguanine nucleotides (TGNs) for immunosuppression. The TGNs and other metabolites (e.g. 6-methyl-mecaptopurine ribonucleotides) inhibit de novo purine synthesis and purine nucleotide interconversions. |
| Document | Type | Information Source | |
|---|---|---|---|
| AZAMUN Film coated tablet | MPI, Generic | Health Products Regulatory Authority (ZA) | |
| IMUPRIN Film-coated tablet | MPI, EU: SmPC | Υπουργείο Υγείας (CY) | |
| IMURAN Tablet | MPI, EU: SmPC | Medicines & Healthcare Products Regulatory Agency (GB) | |
| JAYEMPI Oral suspension | MPI, EU: SmPC | European Medicines Agency (EU) |
Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide.