Source: Health Sciences Authority (SG) Revision Year: 2011 Publisher: <u>Manufacturer:</u> Sunward Pharmaceutical Sdn. Bhd., No. 9,11&17, Jalan Kempas 4, Taman Perindustrian Tampoi Indah, 81200 Johor Bahru, Johor, Malaysia. Tel: 07-2367531, 2367967, 2367972 Fax: 07-2367532 ...
MENDICOF.
Pharmaceutical Form |
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Syrup. A clear, red syrup with plum flavour. |
Each 5ml contains:
Dexchlorpheniramine maleate 2mg
Pseudoephedrine HCI 30mg
Dextromethorphan HBr 15mg
Active Ingredient | Description | |
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Demorphan |
Dextromethorphan is a non-opioid antitussive drug. The major metabolite of dextromethorphan, dextrorphan, binds with high affinity to σ-receptors to produce its antitussive activity without exhibiting the classic opiate effects that occur from binding into μ- and δ-receptors. In larger than therapeutic doses, dextrorphan is also an antagonist of N-methyl-D-aspartate (NMDA) receptors. |
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Dexchlorpheniramine |
Dexchlorpheniramine, the d-isomer of the racemic compound chlorpheniramine, is two times more active than chlorpheniramine. Dexchlorpheniramine does not prevent the release of histamine, but rather, competes with free histamine for binding at the H1-receptor sites, and competitively antagonizes the effects of histamine on H1-receptors in the GI tract, uterus, large blood vessels, and bronchial muscle. Blockade of H1-receptors also suppresses the formation of oedema, flare, and pruritus that result from histaminic activity. Since dexchlorpheniramine binds to central and peripheral H1-receptors, sedative effects are likely to occur. Dexchlorpheniramine has high antihistaminic activity, moderate anticholinergic effects and minimal sedative effects. |
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Pseudoephedrine |
Pseudoephedrine is a sympathomimetic agent with direct and indirect effects on adrenergic receptors. It has alpha and beta adrenergic activity and some stimulant effect on the central nervous system. The sympathomimetic effect of pseudoephedrine produces vasoconstriction which in turn relieves nasal congestion. |
List of Excipients |
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Pack size: A bottle of 60ml, 100ml and 120ml.
Manufacturer:
Sunward Pharmaceutical Sdn. Bhd., No. 9,11&17, Jalan Kempas 4, Taman Perindustrian Tampoi Indah, 81200 Johor Bahru, Johor, Malaysia.
Tel: 07-2367531, 2367967, 2367972 Fax: 07-2367532
Drug | Countries | |
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MENDICOF | Singapore |
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