Chemical formula: C₁₈H₂₅NO Molecular mass: 271.404 g/mol PubChem compound: 5360696
Dextromethorphan is a non-opioid antitussive drug. The major metabolite of dextromethorphan, dextrorphan, binds with high affinity to σ-receptors to produce its antitussive activity without exhibiting the classic opiate effects that occur from binding into μ- and δ-receptors. In larger than therapeutic doses, dextrorphan is also an antagonist of N-methyl-D-aspartate (NMDA) receptors.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| R05DA09 | Dextromethorphan | R Respiratory system → R05 Cough and cold preparations → R05D Cough suppressants, excl. combinations with expectorants → R05DA Opium alkaloids and derivatives |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| BENYLIN DRY COUGHS Syrup | Medicines & Healthcare Products Regulatory Agency (GB) | MPI, EU: SmPC | |
| Vicks Cough Syrup with Honey for Dry Coughs | Medicines & Healthcare Products Regulatory Agency (GB) | MPI, EU: SmPC |
Demorphan is an active ingredient of these brands:
United States (US)
Austria (AT)
Canada (CA)
Croatia (HR)
Cyprus (CY)
Ecuador (EC)
Estonia (EE)
Finland (FI)
France (FR)
Germany (DE)
Hong Kong (HK)
Ireland (IE)
Israel (IL)
Lithuania (LT)
Malta (MT)
Mexico (MX)
New Zealand (NZ)
Nigeria (NG)
Poland (PL)
Romania (RO)
Singapore (SG)
South Africa (ZA)
Spain (ES)
Turkey (TR)
United Kingdom (UK)
Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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