Chemical formula: C₁₈H₂₈N₂O Molecular mass: 288.428 g/mol PubChem compound: 2474
Bupivacaine is an amide-type, long-acting local anesthetic. Bupivicaine reversibly binds to specific sodium ion channels in the neuronal membrane, resulting in a decrease in the voltage-dependent membrane permeability to sodium ions and membrane stabilization; inhibition of depolarization and nerve impulse conduction; and a reversible loss of sensation.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| N01BB01 | Bupivacaine | N Nervous system → N01 Anesthetics → N01B Anesthetics, local → N01BB Amides |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| MARCAINE Solution for injection | FDA, National Drug Code (US) | MPI, US: SPL/Old | |
| MARCAIN POLYAMP STERIPACK Solution for injection | Medicines & Healthcare Products Regulatory Agency (GB) | MPI, EU: SmPC |
Bupivacaine is an active ingredient of these brands:
United States (US)
Austria (AT)
Brazil (BR)
Canada (CA)
Ecuador (EC)
Estonia (EE)
Finland (FI)
Hong Kong (HK)
Ireland (IE)
Israel (IL)
Italy (IT)
Japan (JP)
Lithuania (LT)Malta (MT)
Mexico (MX)
Netherlands (NL)
New Zealand (NZ)Poland (PL)
Romania (RO)
Singapore (SG)
Spain (ES)
Turkey (TR)Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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