Clotrimazole

Chemical formula: C₂₂H₁₇ClN₂  Molecular mass: 344.837 g/mol  PubChem compound: 2812

Active ingredient description

Clotrimazole acts against fungi by inhibiting ergosterol synthesis. Inhibition of ergosterol synthesis leads to structural and functional impairment of the fungal cytoplasmic membrane. Clotrimazole has a broad antimycotic spectrum of action in vitro and in vivo, which includes dermatophytes, yeasts, moulds, etc.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code Group title Classification
A01AB18 Clotrimazole A Alimentary tract and metabolism → A01 Stomatological preparations → A01A Stomatological preparations → A01AB Antiinfectives and antiseptics for local oral treatment
Discover more medicines within A01AB18
D01AC01 Clotrimazole D Dermatologicals → D01 Antifungals for dermatological use → D01A Antifungals for topical use → D01AC Imidazole and triazole derivatives
Discover more medicines within D01AC01
G01AF02 Clotrimazole G Genito urinary system and sex hormones → G01 Gynecological antiinfectives and antiseptics → G01A ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS → G01AF Imidazole derivatives
Discover more medicines within G01AF02

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title Information Source Document Type  
CANESTEN THRUSH INTERNAL CREAM 10% w/w Vaginal cream Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC
CANESTEN BIFONAZOLE ONCE DAILY Cream Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC
CLOTRIMADERM Vaginal cream Health Products and Food Branch (CA) MPI, CA: SPM
Canesten 100mg Pessary Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC

Structural formula

Graphic representation of the active ingredient's molecular structure

3D molecular structure

3D representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 23593-75-1
DrugBank Drug: DB00257
KEGG Drug: D00282
PubChem Compound: 2812
RxNorm Ingredient: 2623
SNOMED-CT Concept: 387325003
Clotrimazole (substance)
UNII Identifier: G07GZ97H65
CLOTRIMAZOLE

Medicines

Clotrimazole is an active ingredient of these brands:

United States (US)

Australia (AU)

Austria (AT)

Canada (CA)

Cyprus (CY)

Ecuador (EC)

Estonia (EE)

Finland (FI)

France (FR)

Hong Kong (HK)

Ireland (IE)

Israel (IL)

Japan (JP)

Lithuania (LT)

Malta (MT)

Mexico (MX)

Netherlands (NL)

New Zealand (NZ)

Nigeria (NG)

Poland (PL)

Romania (RO)

Singapore (SG)

Spain (ES)

Tunisia (TN)

Turkey (TR)

United Kingdom (UK)

Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide.

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