Chemical formula: C₄₁H₆₄O₁₄ Molecular mass: 780.939 g/mol PubChem compound: 2724385
Digoxin increases contractility of the myocardium by direct activity. The primary action of digoxin is specifically to inhibit adenosine triphosphatase, and thus sodium-potassium (Na+ - K+) exchange activity, the altered ionic distribution across the membrane resulting in an augmented calcium ion influx and thus an increase in the availability of calcium at the time of excitation-contraction coupling. The potency of digoxin may therefore appear considerably enhanced when the extracellular potassium concentration is low, with hyperkalaemia having the opposite effect.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| C01AA05 | Digoxin | C Cardiovascular system → C01 Cardiac therapy → C01A Cardiac glycosides → C01AA Digitalis glycosides |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| DIGOXIN Solution for injection | Medicines & Healthcare Products Regulatory Agency (GB) | MPI, EU: SmPC | |
| LANOXIN Solution for injection | FDA, National Drug Code (US) | MPI, US: SPL/PLR | |
| LANOXIN Tablet | FDA, National Drug Code (US) | MPI, US: SPL/PLR | |
| DIGOXIN Tablets | Medicines & Healthcare Products Regulatory Agency (GB) | MPI, EU: SmPC |
Digoxin is an active ingredient of these brands:
Brazil (BR)Cyprus (CY)Ecuador (EC)Estonia (EE)France (FR)Hong Kong (HK)Ireland (IE)Israel (IL)Japan (JP)Mexico (MX)Netherlands (NL)New Zealand (NZ)Singapore (SG)South Africa (ZA)Spain (ES)Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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