The two active substances have a complementary antihypertensive effect. Once absorbed, enalapril is hydrolyzed to enalaprilat, a substance that inhibits ACE. This inhibition results in a decrease in plasma angiotensin II, which leads to an increase in plasma renin activity and a decrease in aldosterone secretion. Enalapril has an antihypertensive effect even in cases of hypertension with low renin. Nitrendipine is a calcium antagonist of the 1-4 dihydropyridine group that acts as an antihypertensive agent. The mechanism of action of nitrendipine is based on the inhibition of the flow of calcium ions in the smooth muscle fibers of the vessels.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| C09BB06 | Enalapril and nitrendipine | C Cardiovascular system → C09 Agents acting on the renin-angiotensin system → C09B ACE inhibitors, combinations → C09BB ACE inhibitors and calcium channel blockers |
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