Ibuprofen

Chemical formula: C₁₃H₁₈O₂ Molecular mass: 206.281 g/mol PubChem compound: 3672

Therapeutic indications

Ibuprofen is indicated for:

Rheumatoid arthritis

Population group: only adolescents (12 years - 18 years old) , adults (18 years old or older)

For relief of the signs and symptoms of rheumatoid arthritis.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

1,200-3,200 mg in 3-4 divided doses daily

Osteoarthritis

Population group: only adults (18 years old or older)

Osteoarthritis

For this indication, competent medicine agencies globally authorize below treatments (click for details):

1,200-3,200 mg in 3-4 divided doses daily

Seronegative arthritis

Population group: only adolescents (12 years - 18 years old) , adults (18 years old or older)

Seronegative arthritis

For this indication, competent medicine agencies globally authorize below treatments (click for details):

1,200-2,400 mg in 3-4 divided doses daily

Painful swelling of joint

Population group: only adolescents (12 years - 18 years old) , adults (18 years old or older)

Painful swelling of joint

For this indication, competent medicine agencies globally authorize below treatments (click for details):

600 mg in 2-4 times daily

1-4 spreads daily

Juvenile rheumatoid arthritis

Population group: only infants (40 days - 1 year old) , children (1 year - 12 years old) , adolescents (12 years - 18 years old)

Ibuprofen is indicated for its analgesic and anti-inflammatory effects in the treatment of juvenile rheumatoid arthritis.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

20-40 mg/kg in 3-4 divided doses daily

Mild to moderate pain

Population group: only infants (40 days - 1 year old) , children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 - 65 years old)

In adults and children over 12 years (>40 kg): Short term treatment of pain of mild to moderate intensity.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

400 mg 1-4 times daily

20 mg/kg in 3-4 divided doses daily up to 3 days

75-600 mg daily depending on the patient’s age and body weight

Fever

Population group: only infants (40 days - 1 year old) , children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 - 65 years old)

Fever

For this indication, competent medicine agencies globally authorize below treatments (click for details):

400 mg in 1-4 times daily

20 mg/kg in 3-4 divided doses daily up to 3 days

75-600 mg daily depending on the patient’s age and body weight

Backache

Population group: only adolescents (12 years - 18 years old) , adults (18 years old or older)

Backache

For this indication, competent medicine agencies globally authorize below treatments (click for details):

1-4 spreads daily

400 mg 1-4 times daily

Muscular pain, sprains, strains, sports injuries

Population group: only adolescents (12 years - 18 years old) , adults (18 years old or older)

at least one of

Myalgia
Strain
Traumatic injury of skeletal muscle
Sprain of ligament

For this indication, competent medicine agencies globally authorize below treatments (click for details):

1-4 spreads daily

200 mg once daily for 1-5 days

400 mg 1-4 times daily

Neuralgia

Population group: only adolescents (12 years - 18 years old) , adults (18 years old or older)

Neuralgia

For this indication, competent medicine agencies globally authorize below treatments (click for details):

1-4 spreads daily

400 mg 1-4 times daily

Dysmenorrhoea

Population group: women, only adolescents (12 years - 18 years old) , adults (18 - 65 years old)

Period pain

For this indication, competent medicine agencies globally authorize below treatments (click for details):

400 mg 1-3 times daily

Patent ductus arteriosus

Population group: only newborns (0 - 40 days old) , infants (40 days - 1 year old)

Treatment of a haemodynamically significant patent ductus arteriosus in preterm newborn infants less than 34 weeks of gestational age.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

10 mg/kg once given after the first 6 hours of life and thereafter 2 injections of 5 mg/kg given at 24-hour intervals

Non-specific inflammations of the female genital system

Population group: women, only adults (18 years old or older)

Inflammatory disease of female genital structure

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Vaginal washes 1-2 times daily

Pre- and post-operative in gynecological surgeries

Population group: women, only adults (18 years old or older)

Operation on female genital organs

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Vaginal washes 1-2 times daily

Contraindications

Ibuprofen is contraindicated in the following cases:

Pregnancy

Pregnancy

Peptic ulcer, gastrointestinal haemorrhage

at least one of

Peptic ulcer
H/O: peptic ulcer
Gastrointestinal hemorrhage
History of gastrointestinal bleed

Severe heart failure

Heart failure New York Heart Assosiation Class IV

Severe renal failure

at least one of

Renal failure stage 5: Kidney failure (GFR <15 mL/min/1.73 m2 or dialysis)

Severe hepatic failure

Hepatic failure stage IV

Colitis ulcerosa

Colitis gravis

Hemorrhagic diathesis

at least one of

Familial hemorrhagic diathesis
At risk of hemorrhage

Acetylsalicylic acid

Acetylsalicylic acid

Known or suspected necrotising enterocolitis

Necrotizing enterocolitis in fetus OR newborn

Congenital heart disease in which patency of the ductus arteriosus is necessary

at least one of

Pulmonary vein atresia
Tetralogy of Fallot
Coarctation of aorta

History of hypersensitivity reactions after taking NSAIDs

Non-steroidal anti-inflammatory drug allergy

History of gastrointestinal bleeding or perforation related to previous NSAID therapy

at least one of

Duodenal ulcer caused by non-steroidal anti-inflammatory drug
Oesophageal ulcer caused by aspirin

Topical application on broken or damaged skin

Skin or mucosa lesion

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