Ivacaftor and Lumacaftor

Active ingredient description

The combined effect of lumacaftor and ivacaftor is increased quantity and function of F508delCFTR at the cell surface, resulting in increased chloride ion transport. The exact mechanisms by which lumacaftor improves cellular processing and trafficking of F508delCFTR and ivacaftor potentiates F508del-CFTR are not known.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code Group title Classification
R07AX30 Ivacaftor and lumacaftor R Respiratory system → R07 Other respiratory system products → R07A Other respiratory system products → R07AX Other respiratory system products
Discover more medicines within R07AX30

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title Information Source Document Type  
ORKAMBI Film-coated tablet European Medicines Agency (EU) MPI, EU: SmPC
ORKAMBI Granules European Medicines Agency (EU) MPI, EU: SmPC

External identifiers

RxNorm Ingredient: 1655927

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