Sumatriptan Other names: Sumatriptan succinate

Chemical formula: C₁₄H₂₁N₃O₂S  Molecular mass: 295.4 g/mol  PubChem compound: 5358

Active ingredient description

Sumatriptan has been demonstrated to be a specific and selective 5-Hydroxytryptamine1 (5HT1D) receptor agonist with no effect on other 5HT receptor (5-HT2 - 5-HT7) subtypes. The vascular 5-HT1D receptor is found predominantly in cranial blood vessels and mediates vasoconstriction.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC Group Classification
N02CC01 Sumatriptan N Nervous system → N02 Analgesics → N02C Antimigraine preparations → N02CC Selective serotonin (5HT1) agonists
Discover more medicines within N02CC01

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Document Type Information Source  
 IMIGRAN Solution for injection MPI, EU: SmPC Medicines & Healthcare Products Regulatory Agency (GB)
 IMITREX Solution for injection MPI, US: SPL/PLR FDA, National Drug Code (US)
 IMITREX Film-coated tablet MPI, US: SPL/PLR FDA, National Drug Code (US)
 IMIGRAN Nasal spray, solution MPI, EU: SmPC Medicines & Healthcare Products Regulatory Agency (GB)
 IMITREX Nasal spray MPI, US: SPL/PLR FDA, National Drug Code (US)
 IMIGRAN Tablet MPI, EU: SmPC Medicines & Healthcare Products Regulatory Agency (GB)

Structural formula

Graphic representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 103628-46-2
CAS Substance: 103628-48-4
DrugBank Drug: DB00669
KEGG Drug: D00451
PubChem Compound: 5358
RxNorm Ingredient: 37418
SNOMED-CT Concept: 395892000
Sumatriptan (substance)
UNII Identifier: 8R78F6L9VO
SUMATRIPTAN

Medicines

Sumatriptan is an active ingredient of these brands:

United States (US)

Australia (AU)

Austria (AT)

Brazil (BR)

Canada (CA)

  • IMITREX as SUMATRIPTAN SUCCINATE
  • (combination) SUVEXX as SUMATRIPTAN SUCCINATE

Croatia (HR)

Cyprus (CY)

Ecuador (EC)

Estonia (EE)

Finland (FI)

France (FR)

Germany (DE)

Hong Kong (HK)

Ireland (IE)

Israel (IL)

Italy (IT)

Japan (JP)

Lithuania (LT)

Malta (MT)

Mexico (MX)

Netherlands (NL)

New Zealand (NZ)

Poland (PL)

Romania (RO)

Singapore (SG)

South Africa (ZA)

Spain (ES)

Tunisia (TN)

Turkey (TR)

United Kingdom (UK)

Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide.

 
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