Tislelizumab is a humanised immunoglobulin G4 (IgG4) variant monoclonal antibody against PD-1, binding to the extracellular domain of human PD-1. It competitively blocks the binding of both PD-L1 and PD-L2, inhibiting PD-1-mediated negative signalling and enhancing the functional activity in T cells in in vitro cell-based assays.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| L01FF09 | L Antineoplastic and immunomodulating agents → L01 Antineoplastic agents → L01F Monoclonal antibodies and antibody drug conjugates → L01FF PD-1/PDL-1 (Programmed cell death protein 1/death ligand 1) inhibitors | |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| TEVIMBRA Concentrate for solution for infusion | European Medicines Agency (EU) | MPI, EU: SmPC | |
| TIZVENI Concentrate for solution for infusion | European Medicines Agency (EU) | MPI, EU: SmPC |
Tislelizumab is an active ingredient of these brands:
Austria (AT)Croatia (HR)Estonia (EE)Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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