Verapamil Other names: Verapamil hydrochloride

Chemical formula: C₂₇H₃₈N₂O₄ Molecular mass: 454.602 g/mol PubChem compound: 2520

Therapeutic indications

Verapamil is indicated for:

Mild to moderate hypertension

Population group: only adults (18 years old or older)

Hypertension

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Angina pectoris

Population group: only adults (18 years old or older)

Angina pectoris, including Prinzmetal’s angina (coronary spasm, vasospastic angina).

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Angina pectoris

Population group: only adults (18 years old or older)

Angina pectoris, including Prinzmetal’s angina (coronary spasm, vasospastic angina).

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Supraventricular tachycardias

Population group: only minors (0 - 18 years old) , adults (18 years old or older)

Supraventricular tachycardias such as paroxysmal supraventricular tachycardia, atrial fibrillation/flutter with rapid ventricular response (except in WPW syndrome or LGL syndrome).

For this indication, competent medicine agencies globally authorize below treatments (click for details):

5 mg initial dose and, if the therapeutic effect is not achieved, a further 5 mg may be injected after 5 to 10 minutes

For patients up to 2 years old 20 mg 2-3 times daily and for patients >2 years old 40-120 mg 2-3 times daily

For patients 0-1 year old 0.1-0.2 mg/kg bodyweight once and for patients 1-15 years old 0.1-0.3 mg/kg bodyweight once

Supraventricular tachycardias

Population group: only minors (0 - 18 years old) , adults (18 years old or older)

Supraventricular tachycardias such as paroxysmal supraventricular tachycardia, atrial fibrillation/flutter with rapid ventricular response (except in WPW syndrome or LGL syndrome).

For this indication, competent medicine agencies globally authorize below treatments (click for details):

For patients up to 2 years old 20 mg 2-3 times daily and for patients >2 years old 40-120 mg 2-3 times daily

Contraindications

Verapamil is contraindicated in the following cases:

Cardiogenic shock

Second or third degree AV block

at least one of

Second degree atrioventricular block
Complete atrioventricular block

Sick sinus syndrome

Sinoatrial block

Uncompensated heart failure

Decompensated cardiac failure

Hypotension of less than 90mmHg systolic

Hypotension

Atrial fibrillation/flutter in the presence of an accessory bypass tract

at least one of

Atrial fibrillation
Atrial flutter

Bradycardia of less than 50 beats/minute

Bradycardia

Ivabradine

Grapefruit

Dantrolene

Heart failure with reduced ejection fraction <35% and/or pulmonary wedge pressure >20 mmHg

Heart failure with reduced ejection fraction and additionally Pulmonary hypertension

Porphyria

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Verapamil Other names: Verapamil hydrochloride

Therapeutic indications

Mild to moderate hypertension

40-120 mg 3-4 times daily

Angina pectoris

120 mg 3-4 times daily

Angina pectoris

120 mg 3-4 times daily

Supraventricular tachycardias

40-120 mg 3-4 times daily

5 mg initial dose and, if the therapeutic effect is not achieved, a further 5 mg may be injected after 5 to 10 minutes

For patients up to 2 years old 20 mg 2-3 times daily and for patients >2 years old 40-120 mg 2-3 times daily

For patients 0-1 year old 0.1-0.2 mg/kg bodyweight once and for patients 1-15 years old 0.1-0.3 mg/kg bodyweight once

Supraventricular tachycardias

40-120 mg 3-4 times daily

For patients up to 2 years old 20 mg 2-3 times daily and for patients >2 years old 40-120 mg 2-3 times daily

Contraindications

Cardiogenic shock

Second or third degree AV block

Sick sinus syndrome

Sinoatrial block

Uncompensated heart failure

Hypotension of less than 90mmHg systolic

Atrial fibrillation/flutter in the presence of an accessory bypass tract

Bradycardia of less than 50 beats/minute

Ivabradine

Grapefruit

Dantrolene

Heart failure with reduced ejection fraction <35% and/or pulmonary wedge pressure >20 mmHg

Porphyria

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