ATC Group: C03CA Sulfonamides, plain

The World Health Organization's ATC classification organizes medical drugs based on therapeutic properties, chemical composition, and anatomy. It helps make essential medicines readily available globally and is widely used in the pharmaceutical industry.

Position of C03CA in the ATC hierarchy

Level Code Title
1 C Cardiovascular system
2 C03 Diuretics
3 C03C High-ceiling diuretics
4 C03CA Sulfonamides, plain

Group C03CA contents

Code Title
C03CA01 Furosemide
C03CA02 Bumetanide
C03CA03 Piretanide
C03CA04 Torasemide

Active ingredients in C03CA

Active Ingredient

Bumetanide is a potent loop diuretic with a rapid onset and a short duration of action. The primary site of action is the ascending limb of the loop of Henle where it exerts inhibiting effects on electrolyte reabsorption, causing its diuretic and natriuretic action.

Furosemide inhibits active chloride transport in the thick ascending limb. Re-absorption of sodium, chloride from the nephron is reduced and a hypotonic or isotonic urine produced. The evidence from many experimental studies suggests that furosemide acts along the entire nephron with the exception of the distal exchange site.

Piretanide is a loop diuretic for the management of fluid retention and treatment of mild to moderate hypertension.

Torasemide is a loop diuretic. Torasemide acts as a salidiuretic by inhibition of renal sodium and chloride reabsorption in the ascending limb of the loop of Henle. Torasemide leads to a gentle removal of edema and especially to an improvement of the working condition of the heart failure by reducing the preload and afterload. In patients with severe to endstage chronic renal failure there is a reduction of aterial blood pressure in addition to removal of edema and maintenance of residual diuresis.

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