Chemical formula: C₂₁H₂₆ClN₃OS Molecular mass: 403.969 g/mol PubChem compound: 4748
Perphenazine is a depressant which blocks dopamine receptors in the central nervous system. It binds to dopamine D1 and D2 receptors and inhibits their activity. Its antiemetic action is mainly due to the inhibition of D2 receptors in the center of the vomiting. Perphenazine also binds to alpha adrenergic receptors and in conjunction with G proteins activate the phosphatidylinositol-calcium system.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| N05AB03 | Perphenazine | N Nervous system → N05 Psycholeptics → N05A Antipsychotics → N05AB Phenothiazines with piperazine structure |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| PERPHENAN Film coated tablet | MPI, EU: SmPC |
Perphenazine is an active ingredient of these brands:
Estonia (EE)Finland (FI)
Israel (IL)Japan (JP)Mexico (MX)
Spain (ES)Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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