ATC Group: J01F Macrolides, lincosamides and streptogramins

The World Health Organization's ATC classification organizes medical drugs based on therapeutic properties, chemical composition, and anatomy. It helps make essential medicines readily available globally and is widely used in the pharmaceutical industry.

Position of J01F in the ATC hierarchy

Level Code Title
1 J Antiinfectives for systemic use
2 J01 Antibacterials for systemic use
3 J01F Macrolides, lincosamides and streptogramins

Group J01F contents

Code Title
J01FA Macrolides
J01FF Lincosamides
J01FG Streptogramins

Active ingredients in J01F

Active Ingredient Description
Azithromycin

Azithromycin is a macrolide antibiotic belonging to the azalide group. The molecule is constructed by adding a nitrogen atom to the lactone ring of erythromycin A. The mechanism of action of azithromycin is based upon the suppression of bacterial protein synthesis by means of binding to the ribosomal 50S sub-unit and inhibition of peptide translocation.

Clarithromycin

Clarithromycin is a semi-synthetic derivative of erythromycin A. It exerts its antibacterial action by selectively binding to the 50s ribosomal sub-unit of susceptible bacteria preventing translocation of activated amino acids. It inhibits the intracellular protein synthesis of susceptible bacteria.

Clindamycin

Clindamycin is a lincosamide antibiotic with a primarily bacteriostatic action against Gram-positive aerobes and a wide range of anaerobic bacteria. Lincosamides such as clindamycin bind to the 50S subunit of the bacterial ribosome and inhibit the early stages of protein synthesis.

Dalfopristin
Dirithromycin
Erythromycin

Erythromycin exerts its antimicrobial action by binding to the 50S ribosomal sub-unit of susceptible microorganisms and suppresses protein synthesis. Erythromycin is bacteriostatic and bactericidal depending on its concentration and the type of organism.

Josamycin
Lincomycin

Lincomycin is an antibiotic produced by fermentation of Streptomyces lincolnensis. Lincomycin inhibits bacterial protein synthesis by binding to the 50S subunit of the bacterial ribosome.

Midecamycin
Pristinamycin
Quinupristin
Roxithromycin

Roxithromycin is a semi-synthetic macrolide antibiotic. Roxithromycin is bacteriostatic at low concentrations and bactericidal at high concentrations. It binds to the 50S subunit of the 70S ribosome, thereby disrupting bacterial protein synthesis.

Spiramycin

Antibacterial antibiotic belonging to the macrolides family. Spiramycin inhibits translocation by binding to bacterial 50S ribosomal subunits with an apparent 1:1 stoichiometry. This antibiotic is a potent inhibitor of the binding to the ribosome of both donor and acceptor substrates. Spiramycin induces rapid breakdown of polyribosomes, an effect which has formerly been interpreted as occurring by normal ribosomal run-off followed by an antibiotic-induced block at or shortly after initiation of a new peptide.

Telithromycin

Telithromycin is a semisynthetic derivative of erythromycin A belonging to the ketolides, a class of antibacterial agents related to macrolides.

Related product monographs

Title Information Source Document Type  
AZIMAX Tablet Web Search MPI, US: SPL/PLR
CLAREM Film-coated tablet Υπουργείο Υγείας (CY) MPI, EU: SmPC
CLARITHROMYCIN Film-coated tablets Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC
CLARITHROMYCIN Powder for concentrate for solution for infusion Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC
CLERON Film-coated tablet Υπουργείο Υγείας (CY) MPI, EU: SmPC
CLINDAHEXAL Capsule Health Products Regulatory Authority (ZA) MPI, Generic
CLINDAMYCIN Capsule Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC
CLINDAMYCIN Solution for Injection or Infusion Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC
DALACIN C Capsule Medicines and Medical Devices Safety Authority (NZ) MPI, EU: SmPC
DALACIN CREAM Vaginal Cream Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC
ERMYCIN Film-coated tablet Υπουργείο Υγείας (CY) MPI, EU: SmPC
ERY-TAB Delayed-release tablet FDA, National Drug Code (US) MPI, US: SPL/Old
ERYTHROCIN Film coated tablets Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC
ERYTHROMYCIN Granules for oral suspension Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC
ERYTHROMYCIN Powder for solution for infusion Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC
ERYTHROPED SF Granules Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC
KLACID Film-coated tablet Health Products Regulatory Authority (IE) MPI, EU: SmPC
Klaricid 250mg Tablets Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC
KLERIMED Film coated tablet Υπουργείο Υγείας (CY) MPI, EU: SmPC
LINCOCIN Solution for injection Pharmaceutical Benefits Scheme (AU) MPI, EU: SmPC
PORPHYROCIN Film-coated tablet Υπουργείο Υγείας (CY) MPI, EU: SmPC
ROVAMYCIN Film-coated tablet MPI, EU: SmPC
SYNERCID Powder for solution for injection FDA, National Drug Code (US) MPI, US: SPL/Old
ZEDBAC Powder for solution for infusion Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC
ZITHROMAX Capsule, hard Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC
ZITHROMAX Film-coated tablet / Powder for suspension FDA, National Drug Code (US) MPI, US: SPL/PLR
ZITHROMAX Powder for solution for injection FDA, National Drug Code (US) MPI, US: SPL/PLR