Indications A-Z

RxReasoner presents a comprehensive list of pharmaceutical treatment indications drawn from medicine package inserts issued by authoritative regulatory bodies globally.

This index serves as a valuable tool to quickly access information on the recommended therapeutic approaches for different medical conditions, diseases or symptoms.

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A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Indications starting with 'C'

Indication	Treatments
CA - Carcinoma of breast	22-Oxovincaleukoblastine : Breast carcinoma – only adults (18 years old or older) Melphalan : Carcinoma of breast – only adults (18 years old or older) Methotrexate : Breast carcinoma – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older) Norethisterone : Disseminated breast carcinoma – only adults (18 years old or older)
Calcium deficiency	Calcium : Calcium deficiency – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older) Calcium carbonate : Calcium deficiency – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older) Calcium chloride : Hypocalcaemia, calcium deficiency – only adults (18 years old or older)
Cancer-related anaemia	Epoetin theta : Symptomatic anaemia in non-myeloid malignancies – only adults (18 years old or older)
Candidal balanitis	Clotrimazole : Candidal vulvovaginitis, balanitis Econazole : Mycotic balanitis – men, only adolescents (12 years - 18 years old) , adults (18 years old or older)
Candidal vulvovaginitis	Clotrimazole : Candidal vulvovaginitis, balanitis
Candidemia	Voriconazole : Candidemia – only children (1 year - 12 years old) Voriconazole : Candidemia – only adolescents (12 years - 18 years old) , adults (18 years old or older)
Candidiasis of mouth	Chlorhexidine : Gingivitis, oral surgery, aphthous ulceration, oral candidal infections – only adolescents (12 years - 18 years old) , adults (18 years old or older) Fluconazole : Oropharyngeal candidiasis – only adolescents (12 years - 18 years old) , adults (18 years old or older) Miconazole : Candidosis of the oropharynx – only newborns (0 - 40 days old) , infants (40 days - 1 year old) Miconazole : Candidosis of the oropharynx – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older) Nystatin : Prophylaxis against oral candidosis – only newborns (0 - 40 days old) Posaconazole : Oropharyngeal candidiasis – only adults (18 years old or older)
Candidiasis of skin	Econazole : Cutaneous candidiasis – only adolescents (12 years - 18 years old) , adults (18 years old or older) Terbinafine : Cutaneous candida – only adolescents (12 years - 18 years old) , adults (18 years old or older)
Candidiasis of the esophagus	Fluconazole : Oesophageal candidiasis – only adolescents (12 years - 18 years old) , adults (18 years old or older) Micafungin : Oesophageal candidiasis – only adolescents (12 years - 18 years old) , adults (18 years old or older)
Candidiasis of vagina	Clotrimazole : Candidal vaginitis Econazole : Vaginitis due to Candida albicans – women, only adolescents (12 years - 18 years old) , adults (18 years old or older) Fenticonazole : Vulvovaginal candidiasis – women, only adults (18 years old or older) Miconazole : Vulvovaginal candidosis – women, only adults (18 years old or older)
Candidiasis of vulva	Fenticonazole : Vulvovaginal candidiasis – women, only adults (18 years old or older)
Candiduria	Fluconazole : Candiduria – only adolescents (12 years - 18 years old) , adults (18 years old or older)
Capillaria philippinensis infection	Albendazole : Capillaria philippinensis – only adults (18 - 65 years old)
Capsulitis	Ketoprofen : Arthritis, musculoskeletal syndromes, dysmenorrhea – only adults (18 years old or older)
Carcinoid syndrome diarrhea	Telotristat : Carcinoid syndrome diarrhoea – only adults (18 years old or older)
Carcinoid tumor	Interferon, alfa-2b : Carcinoid tumor – only adults (18 - 65 years old) Octreotide : Gastro-entero-pancreatic endocrine tumours – only adults (18 years old or older)
Carcinoma in situ of bladder	BCG vaccine : Adjuvant therapy after TUR of a superficial papillary transitional cell carcinoma of the urinary bladder – only adults (18 years old or older) BCG vaccine : Primary or concurrent carcinoma-in-situ of the urinary bladder – only adults (18 years old or older) Epirubicin : Papillary transitional cell carcinoma of the bladder, carcinoma-in-situ of the bladder – only adults (18 years old or older) Nadofaragene firadenovec : Non-muscle invasive bladder cancer with carcinoma in situ – only adults (18 years old or older) Nogapendekin alfa : BCG-unresponsive nonmuscle invasive bladder cancer with carcinoma in situ – only adults (18 years old or older)
Carcinoma in situ of esophagus	Nivolumab : Oesophageal squamous cell carcinoma – only adults (18 years old or older) Nivolumab : Oesophageal squamous cell carcinoma – only adults (18 years old or older)
Carcinoma of bladder	Epirubicin : Papillary transitional cell carcinoma of the bladder, carcinoma-in-situ of the bladder – only adults (18 years old or older)
Carcinoma of cervix	Topotecan : Carcinoma of cervix – women, only adults (18 years old or older)
Carcinoma of colon	Bevacizumab : Metastatic carcinoma of the colon or rectum – only adults (18 years old or older)
Carcinoma of oesophagus	Pembrolizumab : First-line treatment of locally advanced unresectable or metastatic carcinoma with PD-L1 with a CPS ≥10 – only adults (18 years old or older)
Carcinoma of pancreas	Mitomycin : Advanced pancreatic carcinoma – only adults (18 years old or older)
Carcinoma of prostate	Abarelix : Advanced prostate cancer – men, only adults (18 years old or older) Buserelin : Advanced hormone dependent prostatic carcinoma – men, only adults (18 years old or older) Cabazitaxel : Prostate cancer – men, only adults (18 years old or older) Docetaxel : Prostate cancer – only adults (18 years old or older) Estradiol : Androgen-dependent carcinoma of the prostate – only adults (18 - 65 years old) Estramustine : Carcinoma of the prostate – men, only adults (18 years old or older)
Carcinoma of stomach	Mitomycin : Advanced metastatic gastric carcinoma – only adults (18 years old or older)
Carcinoma of urinary bladder, superficial	Mitomycin : Superficial urinary bladder carcinoma – only elderly (65 years old or older)
Cardiac arrest	Epinephrine : Cardiac arrest – only adults (18 years old or older) Epinephrine : Cardiac arrest – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) Isoprenaline : Cardiac arrest – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older) Sodium bicarbonate : Cardiac arrest – only adults (18 years old or older)
Cardiac edema	Acetazolamide : Congestive heart failure oedema, drug induced oedema – only adults (18 years old or older) Bumetanide : Oedema – only adults (18 years old or older) Furosemide : Oedema – only infants (40 days - 1 year old) , children (1 year - 12 years old) , adolescents (12 years - 18 years old) Furosemide : Oedema – only adolescents (12 years - 18 years old) , adults (18 years old or older) Hydrochlorothiazide : Edema of heart failure – only infants (40 days - 1 year old) , children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Cardiac resuscitation	Calcium gluconate : Cardiac resuscitation – only adults (18 years old or older)
Cardiac transplant rejection	Tacrolimus : Prophylaxis of transplant rejection in cardiac allograft recipients – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) Tacrolimus : Prophylaxis of transplant rejection in cardiac allograft recipients – only adults (18 years old or older)
Cardiogenic shock	Dobutamine : Cardiac decompensation, disturbed ventricular function – only minors (0 - 18 years old) Dobutamine : Cardiac decompensation, disturbed ventricular function – only adults (18 years old or older)
Cardiopulmonary resuscitation	Atropine : Cardiopulmonary resuscitation – only adults (18 years old or older) Calcium chloride : Cardio-pulmonary resuscitation – only adults (18 years old or older) Epinephrine : Cardiopulmonary resuscitation – only adults (18 years old or older)
Cardiovascular disorder	Simvastatin : Cardiovascular prevention – only adults (18 years old or older)
Cardiovascular event	Atorvastatin : Cardiovascular event – only adults (18 years old or older) Ezetimibe : Cardiovascular events – only adults (18 years old or older)
Cardiovascular event risk	Atorvastatin : Cardiovascular event – only adults (18 years old or older) Ezetimibe : Cardiovascular events – only adults (18 years old or older)
Cardiovascular syphilis	Tetracycline : Syphilis of more than one year's duration – only adolescents (12 years - 18 years old) , adults (18 years old or older)
Carditis due to rheumatic fever	Methylprednisolone : Carditis due to rheumatic fever – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Carnitine deficiency	L-carnitine : Primary and secondary carnitine deficiency – only minors (0 - 18 years old) , adults (18 years old or older)
Carpal tunnel syndrome	Dexamethasone : Carpal tunnel syndrome – only adults (18 years old or older)
Cataplexy	Clomipramine : Cataplexy associated with narcolepsy – only adults (18 years old or older)
Cataplexy and narcolepsy	Clomipramine : Cataplexy associated with narcolepsy – only adults (18 years old or older)
CDKL5 (cyclin-dependent kinase-like 5) deficiency	Ganaxolone : Epileptic seizures associated with cyclindependent kinase-like 5 (CDKL5) deficiency disorder – only children (1 year - 12 years old) , adolescents (12 years - 18 years old)
Central precocious puberty	Leuprorelin : Central precocious puberty – only children (1 year - 12 years old) Triptorelin : Central precocious puberty – only children (1 year - 12 years old)
Central retinal vein occlusion with macular edema	Dexamethasone : Central retinal vein occlusion with macular edema – only adults (18 years old or older) Faricimab : Visual impairment due to macular oedema secondary to retinal vein occlusion – only adults (18 years old or older)
Cerebral atherosclerosis	Meclofenoxate : Cerebral atherosclerosis – only adults (18 years old or older)
Cerebral cortex myoclonus	Piracetam : Cortical myoclonus – only adults (18 years old or older)
Cerebral edema	Dexamethasone : Cerebral edema – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older) Glucose : Cerebral oedema – only minors (0 - 18 years old) , adults (18 years old or older) Mannitol : Raised intracranial pressure, cerebral oedema – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Cerebral palsy	Diazepam : Cerebral palsy – only elderly (65 years old or older) Diazepam : Cerebral palsy – only adults (18 - 65 years old)
Cervical arthritis	Ketoprofen : Arthritis, musculoskeletal syndromes, dysmenorrhea – only adults (18 years old or older)
Cervical thyroid remnant	Thyrotropin : Detection of thyroid remnants and well-differentiated thyroid cancer – only adults (18 years old or older)
Cesarean section	Oxytocin : Caesarean section – women, only adults (18 - 65 years old)
Chancroid	Doxycycline : Chancroid, granuloma inguinale, lymphogranuloma venereum – only adolescents (12 years - 18 years old) , adults (18 years old or older)
CHAPLE (complement hyperactivation, angiopathic thrombosis, protein losing enteropathy) syndrome	Pozelimab : CD55-deficient protein-losing enteropathy – only infants (40 days - 1 year old) , children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 - 65 years old)
Cheloid of skin	Dexamethasone : Keloid scar – only adults (18 years old or older)
Chemical pleurodesis	Lidocaine : Chemical pleurodesis – only adults (18 years old or older)
Chemotherapy-induced nausea and vomiting	Aprepitant : Prevention of nausea and vomiting associated with chemotherapy – only adolescents (12 years - 18 years old) Aprepitant : Prevention of nausea and vomiting associated with chemotherapy – only adults (18 years old or older) Fosaprepitant : Prevention of nausea and vomiting associated with chemotherapy – only infants (40 days - 1 year old) , children (1 year - 12 years old) , adolescents (12 years - 18 years old) Fosaprepitant : Prevention of nausea and vomiting associated with chemotherapy – only adults (18 years old or older) Granisetron : Nausea and vomiting associated with chemotherapy and radiotherapy – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) Granisetron : Nausea and vomiting associated with chemotherapy and radiotherapy – only adults (18 years old or older) Granisetron : Prevention of nausea and vomiting associated with chemotherapy and radiotherapy – only adults (18 years old or older) Ondansetron : Chemotherapy induced nausea and vomiting (CINV) – only minors (0 - 18 years old) Ondansetron : Chemotherapy induced nausea and vomiting (CINV) – only adults (18 years old or older) Palonosetron : Prevention of nausea and vomiting associated with chemotherapy – only infants (40 days - 1 year old) , children (1 year - 12 years old) , adolescents (12 years - 18 years old)
Childhood obesity	Semaglutide : Obesity and body weight above 60 kg – only adolescents (12 years - 18 years old)
Chlamydia trachomatis infection of anus and rectum	Doxycycline : Uncomplicated urethral, endocervical or rectal infection caused by Chlamydia trachomatis – only adults (18 years old or older) Tetracycline : Uncomplicated urethral, endocervical or rectal infections caused by Chlamydia trachomatis – only adolescents (12 years - 18 years old) , adults (18 years old or older)
Chlamydia trachomatis urethritis	Doxycycline : Uncomplicated urethral, endocervical or rectal infection caused by Chlamydia trachomatis – only adults (18 years old or older) Tetracycline : Uncomplicated urethral, endocervical or rectal infections caused by Chlamydia trachomatis – only adolescents (12 years - 18 years old) , adults (18 years old or older)
Chlamydial infection	Spiramycin : Chlamydial infection – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) Spiramycin : Chlamydial infection – only adults (18 - 65 years old)
Cholangiocarcinoma of biliary tract	Futibatinib : Cholangiocarcinoma with a fibroblast growth factor receptor 2 fusion or rearrangement – only adults (18 years old or older) Ivosidenib : Locally advanced or metastatic cholangiocarcinoma with an isocitrate dehydrogenase-1 R132 mutation – only adults (18 years old or older) Pemigatinib : Cholangiocarcinoma with a fibroblast growth factor receptor 2 (FGFR2) fusion or rearrangement – only adults (18 years old or older)
Cholera	Ciprofloxacin : Cholera – only adults (18 years old or older) Doxycycline : Cholera – only children (1 year - 12 years old) Doxycycline : Cholera – only adolescents (12 years - 18 years old) , adults (18 years old or older)
Cholestanol storage disease	Chenodeoxycholic acid : Sterol 27-hydroxylase deficiency, cerebrotendinous xanthomatosis (CTX) – only infants (40 days - 1 year old) , children (1 year - 12 years old) , adolescents (12 years - 18 years old) Chenodeoxycholic acid : Sterol 27-hydroxylase deficiency, cerebrotendinous xanthomatosis (CTX) – only adults (18 - 65 years old)
Cholesterolosis of gallbladder	Ursodeoxycholic acid : X-ray radiolucent (X-ray negative) gallstones – only adults (18 years old or older)
Cholinergic crisis	Atropine : Cholinergic crisis – only adults (18 years old or older)
Choriocarcinoma	Methotrexate : Choriocarcinoma, trophoblastic diseases – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Choroidal retinal neovascularization	Verteporfin : Subfoveal choroidal neovascularisation (CNV) – only adults (18 years old or older)
Chronic active hepatitis	Azathioprine : Auto-immune disorders – only adolescents (12 years - 18 years old) , adults (18 years old or older)
Chronic anal fissure	Glyceryl trinitrate : Chronic anal fissure – only adults (18 years old or older)
Chronic arthritis of juvenile onset	Methylprednisolone : Juvenile chronic arthritis – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Chronic atrial fibrillation	Digoxin : Chronic atrial fibrillation – only newborns (0 - 40 days old) , infants (40 days - 1 year old) , children (1 year - 12 years old) Digoxin : Chronic atrial fibrillation – only adolescents (12 years - 18 years old) , adults (18 years old or older)
Chronic atrial flutter	Digoxin : Chronic atrial flutter – only newborns (0 - 40 days old) , infants (40 days - 1 year old) , children (1 year - 12 years old) Digoxin : Chronic atrial flutter – only adolescents (12 years - 18 years old) , adults (18 years old or older)
Chronic atrophic candidosis	Fluconazole : Chronic atrophic candidosis – only adolescents (12 years - 18 years old) , adults (18 years old or older)
Chronic bronchitis	Metaproterenol : Chronic bronchitis – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 - 65 years old) Salbutamol : Chronic bronchitis – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) Salbutamol : Chronic bronchitis – only adults (18 years old or older)
Chronic congestive heart failure	Bisoprolol : Stable chronic heart failure with reduced systolic ventricular function – only adults (18 years old or older)
Chronic constipation	Prucalopride : Chronic constipation – women, only adults (18 - 65 years old) Prucalopride : Chronic constipation – women, only elderly (65 years old or older)
Chronic cough	Gefapixant : Chronic cough – only adults (18 years old or older)
Chronic eczema of external auditory canal	Fluocinolone : Chronic eczematous external otitis – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Chronic gastritis	Sucralfate : Duodenal ulcer, chronic gastritis, peptic esophagitis – only adolescents (12 years - 18 years old) , adults (18 years old or older)
Chronic generalized exfoliative dermatitis	Betamethasone : Generalised erythroderma – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Chronic graft-versus-host disease	Belumosudil : Chronic graft-versus-host disease – only adolescents (12 years - 18 years old) , adults (18 years old or older)
Chronic granulomatous disease	Interferon gamma-1b : Chronic granulomatous disease (CGD) – only adults (18 - 65 years old)
Chronic hand eczema	Alitretinoin : Severe chronic hand eczema – only adults (18 - 65 years old)
Chronic heart failure	Captopril : Chronic heart failure – only adults (18 years old or older) Carvedilol : Mild-to-severe chronic heart failure of ischemic or cardiomyopathic origin – only adults (18 years old or older) Cilazapril : Chronic heart failure – only adults (18 - 65 years old) Dapagliflozin : Symptomatic chronic heart failure – only adults (18 years old or older) Empagliflozin : Chronic heart failure – only adults (18 years old or older) Ivabradine : Chronic heart failure NYHA II to IV class with systolic dysfunction – only adults (18 years old or older) Losartan : Chronic heart failure – only adults (18 years old or older) Nebivolol : Chronic heart failure (CHF) – only adults (18 years old or older) Vericiguat : Chronic heart failure – only adults (18 years old or older)
Chronic hepatitis C caused by Hepatitis C virus genotype 1	Peginterferon alpha-2b : Chronic hepatitis C (CHC) genotype 1 – only adults (18 - 65 years old)
Chronic idiopathic neutropenia	Filgrastim : Cyclic neutropenia, idiopathic neutropenia – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Chronic idiopathic thrombocytopenic purpura	22-Oxovincaleukoblastine : Idiopathic thrombocytopenic purpura (ITP) – only adults (18 years old or older) Azathioprine : Auto-immune disorders – only adolescents (12 years - 18 years old) , adults (18 years old or older) Methylprednisolone : Idiopathic thrombocytopenic purpura – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older) Prednisolone : Idiopathic thrombocytopenic purpura – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older) Romiplostim : Chronic immune (idiopathic) thrombocytopenic purpura (ITP) – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Chronic idiopathic urticaria	Cetirizine : Seasonal and perennial allergic rhinitis, chronic idiopathic urticaria – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older) Ebastine : Idiopathic chronic urticaria – only adults (18 years old or older) Loratadine : Chronic idiopathic urticaria – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Chronic inflammatory demyelinating polyradiculoneuropathy	Human normal immunoglobulin G : Immunomodulatory therapy in CIDP – only minors (0 - 18 years old) , adults (18 - 65 years old) Immunoglobulins, normal human, IV : Chronic inflammatory demyelinating polyneuropathy (CIDP) – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Chronic interstitial cystitis	Pentosan polysulfate : Bladder pain syndrome – only adults (18 - 65 years old)
Chronic kidney disease	Dapagliflozin : Chronic kidney disease – only adults (18 years old or older) Empagliflozin : Chronic kidney disease – only adults (18 years old or older)
Chronic kidney disease stage 3	Finerenone : Chronic kidney disease (stage 3 and 4 with albuminuria) associated with type 2 diabetes – only adults (18 years old or older)
Chronic kidney disease stage 4	Finerenone : Chronic kidney disease (stage 3 and 4 with albuminuria) associated with type 2 diabetes – only adults (18 years old or older) Sucroferric oxyhydroxide : Chronic kidney disease on dialysis – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 - 65 years old)
Chronic kidney disease stage 5	Sucroferric oxyhydroxide : Chronic kidney disease on dialysis – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 - 65 years old)
Chronic lung disease	Theophylline : Acute exacerbations of the symptoms and reversible airflow obstruction associated with asthma and other chronic lung diseases – only minors (0 - 18 years old) , adults (18 years old or older)
Chronic lymphoid leukemia	22-Oxovincaleukoblastine : Acute lymphocytic leukaemia, chronic lymphocytic leukaemia, acute myelogenous leukaemia, chronic myelogenous leukaemia – only adults (18 years old or older) Acalabrutinib : Chronic lymphocytic leukaemia – only adults (18 years old or older) Bendamustine : Chronic lymphocytic leukaemia – only adolescents (12 years - 18 years old) , adults (18 years old or older) Chlorambucil : Chronic lymphocytic leukaemia – only adults (18 years old or older) Duvelisib : Relapsed or refractory chronic lymphocytic leukaemia – only adults (18 years old or older) Fludarabine : B-cell chronic lymphocytic leukaemia (CLL) – only adults (18 years old or older) Ibrutinib : Chronic lymphocytic leukaemia (CLL) – only adults (18 years old or older) Idelalisib : Chronic lymphoid leukemia – only adults (18 years old or older) Ofatumumab : Chronic lymphocytic leukaemia (CLL) – only adults (18 years old or older) Rituximab : Chronic lymphocytic leukaemia – only adults (18 years old or older) Venetoclax : Chronic lymphocytic leukaemia (CLL) – only adults (18 years old or older) Zanubrutinib : Chronic lymphocytic leukemia – only adults (18 years old or older)
Chronic mucocutaneous candidiasis	Fluconazole : Chronic mucocutaneous candidiasis – only adolescents (12 years - 18 years old) , adults (18 years old or older)
Chronic myeloid leukemia	22-Oxovincaleukoblastine : Acute lymphocytic leukaemia, chronic lymphocytic leukaemia, acute myelogenous leukaemia, chronic myelogenous leukaemia – only adults (18 years old or older) Busulfan : Chronic myeloid leukaemia – only adults (18 - 65 years old) Interferon, alfa-2b : Chronic myelogenous leukaemia – only adults (18 - 65 years old) Ponatinib : Chronic myeloid leukaemia (CML) – only adults (18 years old or older)
Chronic myelomonocytic leukemia, Type II	Azacitidine : Myelodysplastic syndromes, chronic myelomonocytic leukaemia, acute myeloid leukaemia – only adults (18 years old or older)
Chronic non-neuropathic Gaucher's disease	Eliglustat : Gaucher disease type 1 (GD1) – only adults (18 years old or older) Imiglucerase : Non-neuronopathic (Type 1) Gaucher disease, chronic neuronopathic (Type 3) Gaucher disease – only infants (40 days - 1 year old) , children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older) Miglustat : Gaucher disease type 1 – only adults (18 - 65 years old) Velaglucerase alfa : Gaucher disease type 1 – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Chronic obstructive lung disease	Aclidinium : Chronic obstructive pulmonary disease – only adults (18 years old or older) Arformoterol : Bronchoconstriction in patients with chronic obstructive pulmonary disease – only adults (18 years old or older) Budesonide : Chronic obstructive pulmonary disease – only adults (18 years old or older) Eformoterol : Chronic obstructive lung disease – only adults (18 years old or older) Ensifentrine : Chronic obstructive pulmonary disease – only adults (18 years old or older) Glycopyrronium : Chronic obstructive pulmonary disease – only adults (18 years old or older) Indacaterol : Chronic obstructive pulmonary disease (COPD) – only adults (18 years old or older) Ipratropium : Bronchospasm, chronic obstructive pulmonary disease (COPD), asthma, bronchitis – only adolescents (12 years - 18 years old) , adults (18 years old or older) Olodaterol : Chronic obstructive pulmonary disease – only adults (18 years old or older) Salmeterol : Chronic obstructive pulmonary disease (COPD) – only adults (18 years old or older) Tiotropium : Chronic obstructive pulmonary disease – only adults (18 years old or older) Umeclidinium : Chronic obstructive pulmonary disease – only adults (18 years old or older) Vilanterol : Chronic obstructive pulmonary disease (COPD) – only adults (18 years old or older)
Chronic pain	Ethanol : Severe and chronic pain – only adults (18 years old or older) Fentanyl : Severe chronic pain – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) Fentanyl : Severe chronic pain – only adults (18 years old or older) Oxycodone : Severe pain which requires long-term opioid treatment – only adolescents (12 years - 18 years old) , adults (18 years old or older) Ziconotide : Severe, chronic pain – only adults (18 years old or older)
Chronic paranoid psychosis	Zuclopenthixol : Chronic schizophrenia and other chronic psychoses – only adults (18 years old or older)
Chronic rhinosinusitis with multiple nasal polyps	Mepolizumab : Chronic rhinosinusitis with nasal polyps – only adults (18 years old or older)
Chronic schizophrenia	Levosulpiride : Chronic schizophrenia – only adults (18 years old or older) Zuclopenthixol : Chronic schizophrenia and other chronic psychoses – only adults (18 years old or older)
Chronic systolic heart failure	Bisoprolol : Stable chronic heart failure with reduced systolic ventricular function – only adults (18 years old or older) Digoxin : Chronic systolic heart failure – only newborns (0 - 40 days old) , infants (40 days - 1 year old) , children (1 year - 12 years old) Digoxin : Chronic systolic heart failure – only adolescents (12 years - 18 years old) , adults (18 years old or older)
Chronic trophic ulcer of lower limb	Naftidrofuryl : Peripheral vascular disorders – only adults (18 years old or older)
Chronic type B viral hepatitis	Adefovir dipivoxil : Chronic hepatitis B – only adults (18 - 65 years old) Entecavir : Chronic hepatitis B – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) Entecavir : Chronic hepatitis B – only adults (18 years old or older) Interferon, alfa-2b : Chronic hepatitis B – only adults (18 - 65 years old) Peginterferon alpha-2a : Chronic hepatitis B – only adults (18 years old or older) Telbivudine : Chronic hepatitis B – only adults (18 years old or older) Tenofovir alafenamide : Chronic hepatitis B – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Chronic type C viral hepatitis	Dasabuvir : Chronic hepatitis C – only adults (18 years old or older) Interferon, alfa-2b : Chronic hepatitis C – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) Interferon, alfa-2b : Chronic hepatitis C – only adults (18 - 65 years old) Peginterferon alpha-2a : Chronic hepatitis C (CHC) – only adults (18 years old or older) Peginterferon alpha-2b : Chronic hepatitis C – only children (1 year - 12 years old) Ribavirin : Chronic hepatitis C (CHC) – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) Ribavirin : Chronic hepatitis C (CHC) – only adults (18 years old or older) Sofosbuvir : Chronic hepatitis C (CHC) – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Chronic ulcer of skin	Collagenase : Chronic dermal ulcers, burned areas – only adults (18 years old or older)
Chronic urticaria	Omalizumab : Chronic spontaneous urticaria (CSU) – only adolescents (12 years - 18 years old) , adults (18 years old or older)
Chronic viral hepatitis D	Bulevirtide : Chronic hepatitis delta virus (HDV) infection – only adults (18 years old or older)
Chylothorax	Octreotide : Chylothorax – only adults (18 years old or older)
Circadian rhythm sleep disorder of shift work type	Promethazine : Temporary disturbances of sleep pattern – only adults (18 years old or older)
Cirrhosis of liver	Spironolactone : Hepatic cirrhosis – only adults (18 years old or older)
Classical Hodgkin lymphoma	Nivolumab : Classical Hodgkin lymphoma – only adults (18 years old or older) Pembrolizumab : Relapsed or refractory classical Hodgkin lymphoma – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Classical phenylketonuria	Sapropterin : Hyperphenylalaninaemia (HPA) in phenylketonuria (PKU) – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 - 65 years old)
Clinical diabetic nephropathy	Captopril : Type I diabetic nephropathy – only elderly (65 years old or older) Captopril : Type I diabetic nephropathy – only adults (18 - 65 years old)
Clostridium difficile	Vancomycin : Clostridium difficile infection (CDI) – only newborns (0 - 40 days old) , infants (40 days - 1 year old) , children (1 year - 12 years old) Vancomycin : Clostridium difficile infection (CDI) – only adolescents (12 years - 18 years old) , adults (18 years old or older)
Clostridium difficile infection	Fidaxomicin : Clostridioides difficile infection (CDI) – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) Fidaxomicin : Clostridioides difficile infection (CDI) – only adults (18 years old or older) Teicoplanin : Clostridium difficile infection – only adolescents (12 years - 18 years old) , adults (18 years old or older) Vancomycin : Clostridium difficile infection (CDI) – only newborns (0 - 40 days old) , infants (40 days - 1 year old) , children (1 year - 12 years old) Vancomycin : Clostridium difficile infection (CDI) – only adolescents (12 years - 18 years old) , adults (18 years old or older)
Cluster headache	Sumatriptan : Cluster headache – only adults (18 - 65 years old)
Coccidioidomycosis	Fluconazole : Coccidioidomycosis – only adolescents (12 years - 18 years old) , adults (18 years old or older)
Coeliac disease	Prednisolone : Celiac syndrome – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Cold autoimmune haemolytic anaemia	Sutimlimab : Haemolytic anaemia in patients with cold agglutinin disease (CAD) – only adults (18 years old or older)
Colicky pain	Butylscopolamine : Spasm, endoscopy of the genito-urinary tract or gastro- intestinal tract, Irritable Bowel Syndrome – only children (1 year - 12 years old) Butylscopolamine : Spasm, endoscopy of the genito-urinary tract or gastro- intestinal tract, Irritable Bowel Syndrome – only adolescents (12 years - 18 years old) , adults (18 years old or older)
Colitis gravis	Adalimumab : Ulcerative colitis – only adults (18 years old or older) Beclometasone : Ulcerative colitis – only adults (18 - 65 years old) Budesonide : Ulcerative colitis – only adults (18 years old or older) Dexamethasone : Ulcerative colitis – only adults (18 years old or older) Etrasimod : Ulcerative colitis – only adolescents (12 years - 18 years old) , adults (18 years old or older) Filgotinib : Ulcerative colitis – only adults (18 years old or older) Golimumab : Ulcerative colitis – only adults (18 years old or older) Guselkumab : Ulcerative colitis – only adults (18 years old or older) Infliximab : Ulcerative colitis – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) Infliximab : Ulcerative colitis – only adults (18 years old or older) Mesalazine : Mild to moderate active ulcerative colitis – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older) Methylcellulose : Diverticular disease, ulcerative colitis – only adults (18 years old or older) Methylprednisolone : Ulcerative colitis – only infants (40 days - 1 year old) , children (1 year - 12 years old) , adolescents (12 years - 18 years old) Methylprednisolone : Ulcerative colitis – only adults (18 years old or older) Mirikizumab : Moderately to severely active ulcerative colitis – only adults (18 years old or older) Prednisolone : Ulcerative colitis – only adults (18 years old or older) Sulfasalazine : Ulcerative colitis – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older) Tofacitinib : Ulcerative colitis Upadacitinib : Ulcerative colitis – only adults (18 years old or older) Ustekinumab : Ulcerative colitis – only adults (18 years old or older) Vedolizumab : Ulcerative colitis – only adults (18 years old or older)
Collagenous colitis	Budesonide : Collagenous colitis – only adults (18 years old or older)
Colonoscopy	Butylscopolamine : Spasm, endoscopy of the genito-urinary tract or gastro- intestinal tract, Irritable Bowel Syndrome – only children (1 year - 12 years old) Butylscopolamine : Spasm, endoscopy of the genito-urinary tract or gastro- intestinal tract, Irritable Bowel Syndrome – only adolescents (12 years - 18 years old) , adults (18 years old or older) Glucagon : Motility inhibition of the gastrointestinal tract – only adults (18 years old or older) Lidocaine : Bronchoscopy, gastroscopy, colonoscopy, rectoscopy – only adults (18 years old or older)
Colorectal cancer	Aflibercept : Metastatic colorectal cancer (MCRC) – only adults (18 years old or older) Capecitabine : Colorectal cancer – only adults (18 years old or older) Fluorouracil : Colorectal cancer – only adults (18 years old or older) Irinotecan : Colorectal cancer – only adults (18 years old or older) Oxaliplatin : Colorectal cancer – only adults (18 years old or older) Panitumumab : Wild-type RAS metastatic colorectal cancer (mCRC) – only adults (18 years old or older) Ramucirumab : Metastatic colorectal cancer (mCRC) – only adults (18 years old or older) Regorafenib : Colorectal cancer (CRC) – only adults (18 years old or older)
Colostomy present	Methylcellulose : Colostomy, ileostomy, diarrhoea – only adults (18 years old or older)
Complex regional pain syndrome	Calcitonin : Algodystrophy – only adults (18 years old or older)
Computed tomography of whole body with contrast	Iodixanol : CT of the body – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Computerised axial tomography of brain with radiopaque contrast	Iodixanol : Computerized axial tomography of brain – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Computerized axial tomography	Iopromide : Computerized axial tomography – only adults (18 - 65 years old)
Computerized axial tomography of brain	Iopromide : Computerized axial tomography of brain – only adults (18 - 65 years old)
Conduct disorder, solitary aggressive type	Risperidone : Persistent aggression in conduct disorder – only children (1 year - 12 years old) , adolescents (12 years - 18 years old)
Congenital adrenal hyperplasia	Hydrocortisone : Congenital adrenal hyperplasia – only children (1 year - 12 years old) Methylprednisolone : Congenital adrenal hyperplasia – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older) Prednisolone : Congenital adrenal hyperplasia – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Congenital hypofibrinogenemia	Human fibrinogen : Congenital hypofibrinogenaemia, afibrinogenaemia with bleeding tendency – only infants (40 days - 1 year old) , children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Congenital hypothyroidism	Levothyroxine : Congenital hypothyroidism – only newborns (0 - 40 days old) , infants (40 days - 1 year old)
Congenital neutropenia	Filgrastim : Congenital neutropenia – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Congestion of nasal sinus	Ephedrine : Nasal congestion – only adolescents (12 years - 18 years old) , adults (18 years old or older) Oxymetazoline : Nasal congestion – only children (1 year - 12 years old) Oxymetazoline : Nasal congestion – only adolescents (12 years - 18 years old) , adults (18 years old or older) Phenylephrine : Nasal congestion – only adults (18 - 65 years old) Pseudoephedrine : Nasal congestion, sinus congestion – only adolescents (12 years - 18 years old) , adults (18 years old or older) Xylometazoline : Nasal congestion – only adolescents (12 years - 18 years old) , adults (18 years old or older)
Congestive heart failure	Amiloride : Congestive heart failure – only adults (18 - 65 years old) Glyceryl trinitrate : Unresponsive congestive heart failure – only adults (18 years old or older) Isosorbide dinitrate : Severe acute or chronic congestive cardiac failure – only adults (18 years old or older) Isosorbide mononitrate : Congestive heart failure – only adults (18 years old or older) Milrinone : Severe congestive heart failure – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) Milrinone : Severe congestive heart failure – only adults (18 years old or older) Quinapril : Congestive heart failure – only elderly (65 years old or older) Quinapril : Congestive heart failure – only adults (18 - 65 years old) Spironolactone : Congestive heart failure – only adults (18 years old or older)
Conjunctival xerosis	Hypromellose : Dehydration of the cornea and conjunctiva – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Conjunctivitis	Ketotifen : Allergic conditions – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Conscious sedation	Dexmedetomidine : Procedural/awake sedation – only adults (18 years old or older)
Constipation	Glycerol : Constipation – only infants (40 days - 1 year old) Glycerol : Constipation – only children (1 year - 12 years old) Glycerol : Constipation – only adolescents (12 years - 18 years old) , adults (18 years old or older) Lactitol : Constipation – only adults (18 years old or older) Lactitol : Constipation – only infants (40 days - 1 year old) , children (1 year - 12 years old) , adolescents (12 years - 18 years old) Lactulose : Constipation – only minors (0 - 18 years old) , adults (18 years old or older) Magnesium hydroxide : Constipation – only children (1 year - 12 years old) Magnesium hydroxide : Constipation – only adolescents (12 years - 18 years old) , adults (18 years old or older) Methylcellulose : Constipation – only adults (18 years old or older) Methylnaltrexone : Opioid-induced constipation – only adults (18 years old or older) Naldemedine : Opioid-induced constipation (OIC) – only adults (18 years old or older) Naloxegol : Opioid-induced constipation (OIC) – only adults (18 years old or older) Sennosides : Constipation – only children (1 year - 12 years old) Sennosides : Constipation – only adolescents (12 years - 18 years old) , adults (18 years old or older) Sodium picosulfate : Constipation – only infants (40 days - 1 year old) , children (1 year - 12 years old) Sodium picosulfate : Constipation – only adolescents (12 years - 18 years old) , adults (18 years old or older)
Constipation predominant irritable bowel syndrome	Linaclotide : Moderate to severe irritable bowel syndrome with constipation (IBS-C) – only adults (18 years old or older)
Contact dermatitis	Dexchlorpheniramine : Perennial and seasonal allergic rhinitis, vasomotor rhinitis, allergic conjunctivitis, urticaria, angioedema Fluocinonide : Contact dermatitis – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older) Hydrocortisone : Irritant dermatitis, contact allergic dermatitis, insect bite reactions, mild to moderate eczema – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Contraception care	Desogestrel : Contraception – women, only adults (18 - 65 years old)
Contrast echocardiography	Perflutren : Contrast echocardiography – only adults (18 years old or older) Sulfur hexafluoride : Contrast echocardiography – only adults (18 years old or older)
Controlled ovarian stimulation	Cetrorelix : Prevention of premature ovulation – women, only adults (18 - 65 years old) Choriogonadotropin alpha : Follicular maturation and luteinisation – women, only adults (18 - 65 years old) Clomifene : Ovulatory dysfunction, ovulation induction – women, only adults (18 - 65 years old) Corifollitropin alfa : Controlled Ovarian Stimulation (COS) – women, only adults (18 - 65 years old) Follitropin alfa : Stimulation of multifollicular development – women, only adults (18 - 65 years old) Follitropin beta : Controlled ovarian hyperstimulation – women, only adults (18 - 65 years old) Follitropin delta : Controlled ovarian stimulation – women, only adults (18 - 65 years old) Urofollitropin : Controlled ovarian hyperstimulation – women, only adults (18 - 65 years old)
Contusion	Diethylamine salicylate : Lumbago, fibrositis, sciatica, bruises, strains – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older) Ketoprofen : Painful musculoskeletal conditions caused by trauma, pain of non serious arthritis – only adults (18 years old or older)
Corneal stromal oedema	Dexamethasone : Corneal stromal edema – only adults (18 years old or older)
Coronary angiography	Iodixanol : Selective coronary arteriography – only adults (18 years old or older) Iopromide : Coronary angiography – only adults (18 - 65 years old) Regadenoson : Measurement of fractional flow reserve (FFR) – only adults (18 years old or older)
Coronary atherosclerosis	Evolocumab : Established atherosclerotic cardiovascular disease – only adults (18 years old or older)
Cough	Glycerol : Cough, soreness of the throat – only children (1 year - 12 years old) Glycerol : Cough, soreness of the throat – only adolescents (12 years - 18 years old) , adults (18 years old or older)
Cowpox	Tecovirimat : Smallpox, monkeypox, cowpox – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Critical lower limb ischaemia	Iloprost : Severe chronic ischaemia of lower limbs – only adults (18 - 65 years old)
Crohn's disease	Adalimumab : Crohn's disease – only adults (18 years old or older) Adalimumab : Paediatric Crohn's disease – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) Budesonide : Crohn's disease – only adults (18 years old or older) Dexamethasone : Crohn's disease – only adults (18 years old or older) Infliximab : Crohn’s disease – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) Infliximab : Crohn’s disease – only adults (18 years old or older) Mesalazine : Crohn's disease – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older) Methylprednisolone : Crohn's disease – only infants (40 days - 1 year old) , adolescents (12 years - 18 years old) Methylprednisolone : Crohn's disease – only adults (18 years old or older) Prednisolone : Crohn's disease – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) Prednisolone : Crohn's disease – only adults (18 years old or older) Sulfasalazine : Crohn's disease – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older) Upadacitinib : Crohn's disease – only adults (18 years old or older) Ustekinumab : Crohn's disease – only adults (18 years old or older) Vedolizumab : Crohn's disease – only adults (18 years old or older)
Crow's feet	Botulinum toxin type A : Crow’s feet lines seen at maximum smile – only adults (18 - 65 years old)
CRS - cytokine release syndrome	Tocilizumab : Cytokine Release Syndrome (CRS) – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Cryopyrin associated periodic syndrome	Anakinra : Cryopyrin-Associated Periodic Syndromes (CAPS) – only infants (40 days - 1 year old) , children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older) Canacinumab : Cryopyrin associated periodic syndromes (CAPS) – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older) Rilonacept : Cryopyrin-Associated Periodic Syndromes (CAPS) – only adolescents (12 years - 18 years old) Rilonacept : Cryopyrin-Associated Periodic Syndromes (CAPS) – only adults (18 years old or older)
Cryptococcal meningitis	Fluconazole : Cryptococcal meningitis – only newborns (0 - 40 days old) Fluconazole : Cryptococcal meningitis – only infants (40 days - 1 year old) , children (1 year - 12 years old) Fluconazole : Cryptococcal meningitis – only adolescents (12 years - 18 years old) , adults (18 years old or older)
Cryptosporidiasis	Spiramycin : Cryptosporidiosis – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) Spiramycin : Cryptosporidiosis – only adults (18 - 65 years old)
Cyclical neutropaenia	Filgrastim : Cyclic neutropenia, idiopathic neutropenia – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Cycloplegic refraction	Cyclopentolate : Diagnostic purposes for fundoscopy and cycloplegic refraction – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older) Tropicamide : Cycloplegic refraction – only adolescents (12 years - 18 years old) , adults (18 years old or older)
Cystic acne	Dexamethasone : Cystic acne – only adults (18 years old or older)
Cystic fibrosis	Dornase alfa : Cystic fibrosis – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older) Ivacaftor : Cystic fibrosis – only infants (40 days - 1 year old) , children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 - 65 years old) Mannitol : Cystic fibrosis (CF) – only adults (18 - 65 years old)
Cysticercosis of central nervous system	Albendazole : Neurocysticercosis (NCC) – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) Albendazole : Neurocysticercosis (NCC) – only adults (18 - 65 years old)
Cystinosis	Mercaptamine : Cystinosis – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Cystitis	Serrapeptase : Cystitis – only adults (18 years old or older)
Cytomegalovirus infection	Maribavir : Cytomegalovirus (CMV) infection and/or disease – only adults (18 years old or older)

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